Three-year data from the PALISADE study of plozasiran in patients with genetically confirmed familial chylomicronaemia syndrome (FCS), and pooled data from the SHASTA-3 and SHASTA-4 studies in patients with severe hypertriglyceridaemia (sHTG) have confirmed the sustained TG lowering reported at previous stages of the trials and reductions in acute pancreatitis (AP).