Volanesorsen reduces acute pancreatitis in patients with severe hypertriglyceridaemia, according to results of a fixed-effects meta-analysis of individual patient data from three randomised, controlled trials that included patients with a TG level of >500 mg/dL (5.6 mmol/L).1-3 Of the 207 patients in the analysis, reported in the New England Journal of Medicine, 121 received volanesorsen […]
Should TG cut-off for CV risk be lower?
A lower than conventional prognostic cut-off value for TG for CV events has emerged from an analysis of data from a large regional Italian cohort of 14,189 patients aged 18-95 years followed up for 11.2 (5.3-13.2) years. A conventional cut-off value for TG (150 mg/dL [1.7 mmol/L]) and prognostic cut-offs identified from a receiver operating characteristic […]
NICU babies need targeted TG monitoring
Premature babies receiving TG containing nutrition in neonatal intensive care units (NICU) need individualised TG monitoring, according to researchers who compared TG levels in neonates stratified by gestational age (GA), birth weight (BW), and growth restriction status. From 2018 to 2021, 427 infants born at <32 weeks GA or with BW <1,500 gm were included […]
Fresh support for remnant cholesterol measurement and management
Results of two recent studies linking elevated remnant cholesterol (RC) to premature mortality and atherosclerotic cardiovascular disease (ASCVD) have raised the question of whether RC should be included in risk stratification and as a treatment target.
Phase 3 evinacumab data show efficacy in children with HoFH aged 5-11 years
Evinacumab reduces lipid levels in children with HoFH aged 5-11 years with LDL-C >130 mg/dL (3.4 mmol/L) despite optimised lipid lowering therapy (LLT), according to results of a Phase 3 open label study published in Circulation. In the study of 14 patients, 5-11 years of age with genetically proven HoFH (true homozygotes and compound heterozygotes), […]
Elevated TG linked to MACE in patients with rheumatoid arthritis
In statin-naïve patients with rheumatoid arthritis (RA), elevated TG level has been linked to increased risk of composite major adverse cardiovascular events (MACE). In a nationwide population-based cohort study, carried out in Korea, researchers investigated the relationship between MACE and baseline total cholesterol (TC), LDL-C, HDL-C and TG in this group of patients. During a […]