Solbinsiran shows promise in preclinical research
Solbinsiran (LY3561774), a GalNAc conjugated, small interfering RNA oligonucleotide designed to reduce ANGPTL3 protein expression, has significantly reduced human ANGPTL3 mRNA expression in hepatocytes and serum ANGPTL3 protein expression. Solbinsiran efficacy was measured by RT-qPCR of liver from CD-1 female mice overexpressing human ANGPTL3, and the degree and durability of ANGPTL3 mRNA knockdown and circulating […]
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