Premature babies receiving TG containing nutrition in neonatal intensive care units (NICU) need individualised TG monitoring, according to researchers who compared TG levels in neonates stratified by gestational age (GA), birth weight (BW), and growth restriction status. From 2018 to 2021, 427 infants born at <32 weeks GA or with BW <1,500 gm were included […]
Fresh support for remnant cholesterol measurement and management
Results of two recent studies linking elevated remnant cholesterol (RC) to premature mortality and atherosclerotic cardiovascular disease (ASCVD) have raised the question of whether RC should be included in risk stratification and as a treatment target.
Phase 3 evinacumab data show efficacy in children with HoFH aged 5-11 years
Evinacumab reduces lipid levels in children with HoFH aged 5-11 years with LDL-C >130 mg/dL (3.4 mmol/L) despite optimised lipid lowering therapy (LLT), according to results of a Phase 3 open label study published in Circulation. In the study of 14 patients, 5-11 years of age with genetically proven HoFH (true homozygotes and compound heterozygotes), […]
Elevated TG linked to MACE in patients with rheumatoid arthritis
In statin-naïve patients with rheumatoid arthritis (RA), elevated TG level has been linked to increased risk of composite major adverse cardiovascular events (MACE). In a nationwide population-based cohort study, carried out in Korea, researchers investigated the relationship between MACE and baseline total cholesterol (TC), LDL-C, HDL-C and TG in this group of patients. During a […]
Is abnormal ApoB-48 metabolism key to residual CV risk in type 2 diabetes?
Abnormal metabolism of intestinal lipoproteins containing ApoB-48 may help to explain the residual risk of cardiovascular disease (CVD) in patients with type 2 diabetes (T2D) on statin therapy. This suggestion has emerged from a study which compared the kinetics of ApoB-48- and ApoB-100-containing lipoproteins in 11 overweight/obese individuals with T2D with those in 11 control […]
Remnant cholesterol and TG linked to pancreatic fat
Remnant cholesterol and triglyceride (TG) – but not LDL-C or total cholesterol (TC) – have been linked to intra-pancreatic fat deposition (IPFD) in a general population study of 348 individuals in New Zealand. All participants underwent abdominal MRI and IPFD was quantified. Blood samples were collected in the fasted state for lipid analysis, and linear […]
