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What can we learn from kinetic studies of ANGPTL3-loss of function variants, and how do their effects compare to those of apoC3-LOF variants?

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Jan Borén, University of Gothenburg, Sweden, compares the post-prandial effects of apoC3- and ANGPTL3-loss of function variants on triglyceride rich lipoprotein lipolysis and multiple lipid levels seen in kinetic studies, and considers their relevance for coronary heart disease risk reduction.

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Financial support was provided as a GMG Knowledge Gap Grant from Pfizer Inc. Arrowhead Pharmaceuticals
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