Results of a Mendelian randomisation (MR) study support APOC3 inhibition as a therapeutic option for aortic stenosis (AS) treatment. Analysis of TG level and AS data from genome-wide association studies confirmed that the genetically predicted TG levels were significantly associated with increased risk of AS (IVW: OR 1.28 per standard deviation increase in genetically predicted log TG level, 95% CI 1.18-1.39, p<0.0001) as seen in previous studies.
Educational partners and supporters
Financial support was provided as a GMG Knowledge Gap Grant from Pfizer Inc.
Financial support was provided as a GMG Knowledge Gap Grant from Pfizer Inc.
Financial support was provided as a GMG Knowledge Gap Grant from Pfizer Inc.
