Professor M Mahmood Hussain
Disclosure details
None declaredDepartment of Foundations of Medicine, NYU Long Island School of Medicine, Mineola, New York, USA
Dr Hussain obtained his Ph.D. in 1984 from Oklahoma State University and Lic. Med. (1986) from the University of Copenhagen. He did his postdoctoral work at Boston University School of Medicine and The Gladstone Institutes of the University of California, San Francisco. He joined the Medical College of Pennsylvania as an assistant professor in 1991 and became an associate professor in 1995. Then he moved to SUNY Downstate Medical Center in 1999 as an associate professor and became a tenured professor in 2002. He was nominated as a Distinguished Professor in 2014. In 2016, he accepted a new position as a Director of Basic Science and Director of the Diabetes and Obesity Center at Winthrop University Hospital. In 2019, he became Professor and Endowed Chair, Department of Foundations of Medicine, NYU Langone School of Medicine. He was elected as a Fellow of the American Heart Association in 2001. He established a company, Chylos, Inc. in 2003 and was president until 2017. He also established the Abetalipoproteinemia and Related Disorders Foundation and has been the Founding President since 2019.
Since his postdoctoral training, Dr Hussain has been interested in understanding the metabolism of chylomicrons; lipoprotein synthesized by the intestine to transport dietary fat and fat-soluble vitamins. He showed that bone marrow plays a role in the catabolism of chylomicrons and established cell culture systems to study their biosynthesis. Since he became an assistant professor, he has concentrated on understanding chylomicron assembly. He established cell culture systems to study chylomicron assembly and secretion. Using these systems, he has studied the transport of phospholipids, triglycerides, cholesterol and vitamin A across the intestinal epithelial cells. In addition, he has studied the role of protein-protein interactions between apoB and MTP in lipoprotein assembly. His interest now concentrates on how MTP is regulated by circadian rhythms and microRNAs, and to elucidate the role of MTP in different tissues. He has identified novel microRNAs that regulate plasma LDL and HDL. He has published more than 200 peer-reviewed articles and reviews and holds several patents.
In recognition of his work, he received several awards, such as the Irvine H. Page Award (American Heart Association, National Center), Leonard N. Horowitz Research Award (AHA, Southeastern Pennsylvania Affiliate), AHA Established Investigator Award, Outstanding Achievement Award (2001, International Journal of Molecular Medicine, Crete, Greece), and Promising Inventor Award (2003, The Research Foundation, State University of New York). He served (2001-2002) as the President of the New York Lipid and Vascular Biology Club. In addition, he serves on various grant review committees of the AHA, Veterans Administration and the National Institutes of Health. He was the Chair of the INMP study section of NIH. His research has been supported by grants from the National Institutes of Health and the American Heart Association.
