Professor Dhiraj Yadav
Disclosure details
None declaredProfessor of Medicine and Associate Chief, Clinical Research and Academic Development in the Division of Gastroenterology, Hepatology and Nutrition at the University of Pittsburgh Medical Center, USA
Dr. Yadav is a Professor of Medicine and Associate Chief, Clinical Research and Academic Development in the Division of Gastroenterology, Hepatology and Nutrition at the University of Pittsburgh Medical Center. He is a board-certified gastroenterologist, clinical pancreatologist and an epidemiologist. His clinical practice focuses on pancreatic diseases. His research interests are in the epidemiology of pancreatitis, specifically the role of environmental and other risk factors in the susceptibility, severity, and progression, and ways to alter the natural history of disease. Dr. Yadav has published several key observations in pancreatitis epidemiology, including risk based on alcohol consumption and smoking; population burden, natural history and survival in chronic pancreatitis; lifetime drinking and smoking history in persons with chronic pancreatitis; and racial differences on the risk of pancreatitis. Contributions from him and other investigators have led a widely accepted view in the field that acute, recurrent acute and chronic pancreatitis represent a disease continuum, and laid the foundation for the new mechanistic definition of chronic pancreatitis. He has close to 200 publications, including ~150 original manuscripts.
Dr. Yadav is the co-chair of the adult chronic pancreatitis working group in the NCI/NIDDK-sponsored Chronic Pancreatitis, Diabetes and Pancreatic Cancer Consortium (CPDPC) and co-chair of the NIDDK sponsored Type 1 Diabetes in Acute Pancreatitis Consortium (T1DAPC). He is co-leading several ongoing multicenter studies in pancreatitis – Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies (PROCEED) is the first longitudinal cohort study of chronic pancreatitis in the United States. SpHincterotomy for Acute Recurrent Pancreatitis (SHARP) is a randomized clinical trial evaluating the efficacy of minor papilla sphincterotomy in patients with recurrent acute pancreatitis and pancreas divisum. Diabetes Related to Acute pancreatitis and its mechanism (DREAM) is an observational cohort study which aims to define the risk of diabetes after acute pancreatitis, beta cell function after acute pancreatitis, and the role of immunologic factors in post acute pancreatitis diabetes. A Case-CrossovEr Study deSign to inform tailored interventions to prevent disease progression in Acute Pancreatitis (ACCESS-AP) is an observational study evaluating the role of short-term increase in alcohol consumption in subjects with heavy drinking for precipitating an episode of acute pancreatitis.
Dr. Yadav is a member of the North American Pancreatitis Studies (NAPS2) consortium which was formed by Professor David C. Whitcomb, MD PhD in 2002 to study the role of genetic and environment factors in pancreatitis. In the past 15 years, Dr. Yadav has co-directed the NAPS2 studies. This highly successful collaboration has resulted in several major publications.
